ackground : It is clear that gastric colonization by H. pylori is extremely common among patients with peptic ulcer, particularly when this involves the duodenal mucosa. The precise frequency of H. pylori in various gastroduodenal conditions
varies
somehow, but there is unanimity in confirming a strong association among H. pylori, gastritis, and ulceration. Furthermore atrophic gastritis has been reported to be a precurosor leision for gastric cancer. So we estimated the prevalences of H.
pylori
infection, and serum gastrin level in peptic ulcer and gastric cancer.
Methods : The specimens were obtained by endoscopic biopsy of the gastric antrum from
40 patients with duodenal ulcer, 38 patients with gastric ulcer and 47 patients with gastric
cancer. The urease activity was analyzed for 24 hour on the basis of Campylobacter-like
organism test(CLO test). A change in color of the urea broth from yellow-gold to pink-red
was interpreted as a positive result.
Results :
1) The prevalence of H. pylori infection was significantly higher in duodenal ulcer (75.0%)
than in gastric ulcer (52.6%) and in gastric cancer (38.3%, p<0.05).
2) The mean age of positive groups of CLO test among total 125 cases was significantly
younger (49 years) than the negative groups (62 years, p<0.05). In each diseases, gastric
cancer and duodenal ulcer were also significantly younger in the positive groups than the
negative groups(p<0.05). But there was no significant difference between two groups in
gastric ulcer.
3) Duodenal ulcer patients with positive CLO test had significantly the lower gastrin level
when compared to patients with negative CLO test (p<0.05). In contrst, patients with gastric
cancer or gastric ulcer with positive CLO test had trend of higher gastrin level when
compared to patients with negative CLO test.
Conclusions : There is a strong association between H. pylori and duodenal ulcer. The
influence of H. pylori infection on serum gastrin may be different between gastric disease and
duodenal ulcer.
|